Expert MySQL DBA required to review Mysql DB configration and peformance

I have a large mysql DB running on CentOS6.5. DB size is around 4TB with over 400,000 tables. Need expert advice on recommended mysql configuration (/etc/[login to view URL]) to achieve maximum performance. Server specs: VM CPU:16 cores, RAM:224GB, HDD: 8TB Please only Mysql DBA experts need to apply. Following is the content of /etc/[login to view URL]: # cat /etc/[login to view URL] [mysqld] datadir=/var/lib/mysql socket=/var/lib/mysql/[login to view URL] max_allowed_packet=1024M key_buffer_size=96G thread_cache=1024 table_cache=163840 myisam_sort_buffer_size=1024M #log_slow_queries=/var/log/[login to view URL] user=mysql # Default to using old password format for compatibility with mysql 3.x # clients (those using the mysqlclient10 compatibility package). old_passwords=1 # Disabling symbolic-links is recommended to prevent assorted security risks; # to do so, uncomment this line: # symbolic-links=0 [mysqld_safe] log-error=/var/log/[login to view URL] pid-file=/var/run/mysqld/[login to view URL] ###################################### ###################################### Following is performance summary: mysql> mysql> mysql> mysql> \s -------------- mysql Ver 14.14 Distrib 5.1.73, for redhat-linux-gnu (x86_64) using readline 5.1 Connection id: 355548 Current database: nms Current user: root@localhost SSL: Not in use Current pager: stdout Using outfile: '' Using delimiter: ; Server version: 5.1.73 Source distribution Protocol version: 10 Connection: Localhost via UNIX socket Server characterset: latin1 Db characterset: latin1 Client characterset: latin1 Conn. characterset: latin1 UNIX socket: /var/lib/mysql/[login to view URL] Uptime: 3 days 13 hours 44 min 46 sec Threads: 41 Questions: 993574185 Slow queries: 3511 Opens: 2377801 Flush tables: 1 Open tables: 163746 Queries per second avg: 3218.721 -------------- mysql> ################################